Discovery of 7-Oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists-Reference-Cited by-同舟云学术

Discovery of 7-Oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists

Published:2013-06-04 Issue:11 Volume:56 Page:4482-4496
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Aghazadeh Tabrizi Mojgan¹,Baraldi Pier Giovanni¹,Saponaro Giulia¹,Moorman Allan R.²,Romagnoli Romeo¹,Preti Delia¹,Baraldi Stefania¹,Ruggiero Emanuela¹,Tintori Cristina³,Tuccinardi Tiziano⁴,Vincenzi Fabrizio⁵,Borea Pier Andrea⁵,Varani Katia⁵

Affiliation:

1. Dipartimento di Scienze Chimiche e Farmaceutiche, Università di Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, Italy

2. Research and Development, King Pharmaceuticals, Inc., 4000 Centre Green Way, Suite 300, Cary, North Carolina 27707, United States

3. Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Via Alcide de Gasperi 2, I-53100 Siena, Italy

4. Dipartimento di Farmacia, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy

5. Dipartimento di Scienze Mediche e Sperimentale, Sezione di Farmacologia, Università di Ferrara, 44121, Ferrara, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400182t

Reference47 articles.

1. Structure of a cannabinoid receptor and functional expression of the cloned cDNA

2. Molecular cloning of a human cannabinoid receptor which is also expressed in testis

3. Cannabis: pharmacology and toxicology in animals and humans

4. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1and CB2

5. Role of Endogenous Cannabinoids in Synaptic Signaling

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Rational Design, Synthesis, and Evaluation of Fluorescent CB2 Receptor Ligands for Live-Cell Imaging: A Comprehensive Review;Pharmaceuticals;2023-08-31

2. The chronological evolution of fluorescent GPCR probes for bioimaging;Coordination Chemistry Reviews;2023-04

3. Recent Advances in the Development of Pyrimidine-based CNS Agents;Current Drug Discovery Technologies;2023-03

4. Recent advances in the chemistry of pyrazolo[1,5-a]pyrimidines;Advances in Heterocyclic Chemistry;2023

5. Computational Insights into the Agonist Activity of Cannabinoid Receptor Type-2 Ligands Using Molecular Dynamics Simulation;Current Science;2022-01-25