Detection of Intermediates in the Oxidative Half-Reaction of the FAD-Dependent Thymidylate Synthase from Thermotoga maritima: Carbon Transfer without Covalent Pyrimidine Activation
Author:
Affiliation:
1. Department of Biological Chemistry and ‡Chemical Biology Doctoral Program, University of Michigan Medical School, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109-0606, United States
Funder
National Institute of General Medical Sciences
Division of Chemistry
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/bi500648n
Reference35 articles.
1. An Alternative Flavin-Dependent Mechanism for Thymidylate Synthesis
2. Crystal structure of thy1, a thymidylate synthase complementing protein fromThermotoga maritimaat 2.25 Å resolution
3. Genetic evidence for a novel thymidylate synthase in the halophilic archaeonHalobacterium salinarumand inCampylobacter jejuni
4. Life without dihydrofolate reductase FolA
5. Flavin-Dependent Thymidylate Synthase ThyX Activity: Implications for the Folate Cycle in Bacteria
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