Ultrafast dynamics of fully reduced flavin in catalytic structures of thymidylate synthase ThyX-Reference-Cited by-同舟云学术

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Ultrafast dynamics of fully reduced flavin in catalytic structures of thymidylate synthase ThyX

Published:2021 Issue:39 Volume:23 Page:22692-22702
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Dozova Nadia¹^ORCID,Lacombat Fabien¹^ORCID,Lombard Murielle²^ORCID,Hamdane Djemel²^ORCID,Plaza Pascal¹^ORCID

Affiliation:

1. PASTEUR, Département de chimie, École normale supérieure, PSL University, Sorbonne Université, CNRS, 75005 Paris, France

2. Laboratoire de Chimie des Processus Biologiques, CNRS-UMR 8229, Collège de France, Sorbonne Université, 75005 Paris, France

Abstract

Transient absorption spectroscopy reveals the impact of substrates on the ultrafast dynamics of FADH− in flavin-dependent thymidylate synthase ThyX.

Funder

Agence Nationale de la Recherche

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D1CP03379D

Reference83 articles.

1. Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein

2. Direct Observation of the Participation of Flavin in Product Formation by thyX-Encoded Thymidylate Synthase

3. Oxidase activity of a flavin-dependent thymidylate synthase

4. Crystal Structure of a Flavin-dependent Thymidylate Synthase from Helicobacter pylori strain 26695

5. THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE

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1. Excited-State Properties of Fully Reduced Flavins in Ferredoxin–NADP⁺ Oxidoreductase;The Journal of Physical Chemistry Letters;2023-01-26

2. Photochemical and Molecular Dynamics Studies of Halide Binding in Flavoenzyme Glucose Oxidase;ChemBioChem;2022-08-23

3. Flavoprotein Photochemistry: Fundamental Processes and Photocatalytic Perspectives;The Journal of Physical Chemistry B;2022-04-20

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