Catalytic, Enantioselective Synthesis of Taranabant, a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity-Reference-Cited by-同舟云学术

Catalytic, Enantioselective Synthesis of Taranabant, a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity

Published:2007-04-13 Issue:3 Volume:11 Page:616-623
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Chen Cheng-yi¹,Frey Lisa F.¹,Shultz Scott¹,Wallace Debra J.¹,Marcantonio Karen¹,Payack Joeseph F.¹,Vazquez Enrique¹,Springfield Shawn A.¹,Zhou George¹,Liu Ping¹,Kieczykowski Gerard R.¹,Chen Alex M.¹,Phenix Brian D.¹,Singh Utpal¹,Strine Jeff¹,Izzo Brianne¹,Krska Shane W.¹

Affiliation:

1. Departments of Process Research, Medicinal Chemistry, Center for Material Science and Engineering, Chemical Process Development and Commercialization, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op700026n

Reference33 articles.

1. A Potential Decline in Life Expectancy in the United States in the 21st Century

2. Rimonabant Hydrochloride

3. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

4. Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity

5. Stereoselective Organic Synthesis via Dynamic Kinetic Resolution

Cited by 80 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Catalysis Laboratory at Merck: 20 Years of Catalyzing Innovation;ACS Catalysis;2022-12-20

2. Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution;Organic Process Research & Development;2022-06-07

3. Alkali Metal Alkoxides in Noyori‐Type Hydrogenations;European Journal of Inorganic Chemistry;2021-10-18

4. Thiadiazole Synthesis;Lawesson’s Reagent in Heterocycle Synthesis;2021-09-11

5. Constructing Tertiary Alcohols with Vicinal Stereocenters: Highly Diastereo- and Enantioselective Cyanosilylation of α-Branched Acyclic Ketones and Their Kinetic Resolution;CCS Chemistry;2021-07-23