Complexes of Alkylene-Linked Tacrine Dimers with Torpedo californica Acetylcholinesterase: Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge-Reference-Cited by-同舟云学术

Complexes of Alkylene-Linked Tacrine Dimers with Torpedo californica Acetylcholinesterase: Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge

Published:2006-08-09 Issue:18 Volume:49 Page:5491-5500
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rydberg Edwin H.¹,Brumshtein Boris¹,Greenblatt Harry M.¹,Wong Dawn M.¹,Shaya David¹,Williams Larry D.¹,Carlier Paul R.¹,Pang Yuan-Ping¹,Silman Israel¹,Sussman Joel L.¹

Affiliation:

1. Departments of Structural Biology and Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel, Instituto di Ricerche di Biologia Molecolare P. Angeletti, Pomezia (RM) 00040, Italy, Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, and Computer-Aided Molecular Design Laboratory, Mayo Clinic College of Medicine, Rochester, Minnesota 55905.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060164b

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