Investigation of pH-Responsiveness inside Lipid Nanoparticles for Parenteral mRNA Application Using Small-Angle X-ray Scattering-Reference-Cited by-同舟云学术

Investigation of pH-Responsiveness inside Lipid Nanoparticles for Parenteral mRNA Application Using Small-Angle X-ray Scattering

Published:2020-10-27 Issue:44 Volume:36 Page:13331-13341
ISSN:0743-7463
Container-title:Langmuir
language:en
Short-container-title:Langmuir

Author:

Uebbing Lukas¹^ORCID,Ziller Antje¹,Siewert Christian¹,Schroer Martin A.²^ORCID,Blanchet Clement E.²,Svergun Dmitri I.²,Ramishetti Srinivas³,Peer Dan³^ORCID,Sahin Ugur⁴⁵⁶,Haas Heinrich⁴^ORCID,Langguth Peter¹

Affiliation:

1. Department of Pharmaceutics and Biopharmaceutics, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudingerweg 5, D-55099 Mainz, Germany

2. European Molecular Biology Laboratory (EMBL) Hamburg Outstation c/o DESY, 22607 Hamburg, Germany

3. Laboratory of Precision NanoMedicine, Shmunis School for Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, P.O. Box 39040, Tel Aviv 69978, Israel

4. BioNTech RNA Pharmaceuticals GmbH, An der Goldgrube 12, 55131 Mainz, Germany

5. TRON - Translational Oncology at the University Medical Center of Johannes Gutenberg University Mainz gGmbH, 55099 Mainz, Germany

6. Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University Mainz, 55099 Mainz, Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Electrochemistry,Spectroscopy,Surfaces and Interfaces,Condensed Matter Physics,General Materials Science

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.langmuir.0c02446

Reference39 articles.

1. mRNA-based therapeutics — developing a new class of drugs

2. Current prospects for mRNA gene delivery

3. Incorporation of mRNA in Lamellar Lipid Matrices for Parenteral Administration

4. Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

5. Translating nanoparticulate-personalized cancer vaccines into clinical applications: case study with RNA-lipoplexes for the treatment of melanoma

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