Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish-Reference-Cited by-同舟云学术

Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish

Published:2019-02-27 Issue:10 Volume:141 Page:4214-4218
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Artola Marta^ORCID,Kuo Chi-Lin^ORCID,Lelieveld Lindsey T.,Rowland Rhianna J.¹,van der Marel Gijsbert A.,Codée Jeroen D. C.^ORCID,Boot Rolf G.,Davies Gideon J.¹^ORCID,Aerts Johannes M. F. G.,Overkleeft Herman S.^ORCID

Affiliation:

1. Department of Chemistry, York Structural Biology Laboratory, University of York, Heslington, York YO10 5DD, United Kingdom

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Biotechnology and Biological Sciences Research Council

Royal Society

Genzyme

FP7 Ideas: European Research Council

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

http://pubs.acs.org/doi/pdf/10.1021/jacs.9b00056

Reference26 articles.

1. The carbohydrate-active enzymes database (CAZy) in 2013

2. Demonstration of a deficiency of glucocerebroside-cleaving enzyme in Gaucher's disease.

3. Glucocerebrosidase and Parkinson disease: Recent advances

4. GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology

5. Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Selective labelling of GBA2 in cells with fluorescent β-d-arabinofuranosyl cyclitol aziridines;Chemical Science;2024

2. Animal Models for the Study of Gaucher Disease;International Journal of Molecular Sciences;2023-11-07

3. Structural basis for inhibition of a GH116 β-glucosidase and its missense mutants by GBA2 inhibitors: Crystallographic and quantum chemical study;Chemico-Biological Interactions;2023-10

4. Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor;Bioorganic & Medicinal Chemistry;2023-10

5. Capturing Covalent Catalytic Intermediates by Enzyme Mutants: Recent Advances in Methodologies and Applications;ChemBioChem;2023-04-12