Selective labelling of GBA2 in cells with fluorescent β-<scp>d</scp>-arabinofuranosyl cyclitol aziridines-Reference-Cited by-同舟云学术

Selective labelling of GBA2 in cells with fluorescent β-d-arabinofuranosyl cyclitol aziridines

Published:2024 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Su Qin¹^ORCID,Louwerse Max¹^ORCID,Lammers Rob F.¹^ORCID,Maurits Elmer²,Janssen Max¹,Boot Rolf G.¹,Borlandelli Valentina²,Offen Wendy A.³,Linzel Daniël²,Schröder Sybrin P.²,Davies Gideon J.³^ORCID,Overkleeft Herman S.²^ORCID,Artola Marta¹^ORCID,Aerts Johannes M. F. G.¹^ORCID

Affiliation:

1. Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

2. Department of Bioorganic Synthesis, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands

3. York Structural Biology Laboratory, Department of Chemistry, The University of York, Heslington, York, YO10 5DD, UK

Abstract

Fluorescent β-d-arabinofuranosyl cyclitol aziridine activity-based probes potently and selectively label GBA2 both in vitro and in cellulo, allowing visualization of overexpressed GBA2 using fluorescent microscopy.

Funder

H2020 European Research Council

Chinese Government Scholarship

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D3SC06146A

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