δ-Thiolactones as Prodrugs of Thiol-Based Glutamate Carboxypeptidase II (GCPII) Inhibitors
Author:
Affiliation:
1. Eisai Inc., Baltimore, Maryland 21224, United States
2. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo N. 2, 166 10, Prague 6, Czech Republic
Funder
National Cancer Institute
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm401703a
Reference18 articles.
1. NAAG peptidase inhibitors and their potential for diagnosis and therapy
2. Progress in the discovery and development of glutamate carboxypeptidase II inhibitors
3. Structure-Activity Relationships of Glutamate Carboxypeptidase II (GCPII) Inhibitors
4. Synthesis and Biological Evaluation of Thiol-Based Inhibitors of Glutamate Carboxypeptidase II: Discovery of an Orally Active GCP II Inhibitor
5. Glutamate Carboxypeptidase II in Diagnosis and Treatment of Neurologic Disorders and Prostate Cancer
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