Use of Electrochemical Oxidation and Model Peptides To Study Nucleophilic Biological Targets of Reactive Metabolites: The Case of Rimonabant
Author:
Affiliation:
1. DMPK Design and Biotransformation, CVMD iMed DMPK, AstraZeneca R&D Mölndal, Sweden, Pepparedsleden 1, SE-431 83, Mölndal, Sweden
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/tx500255r
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1. Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose
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