Synthesis of Abasic Locked Nucleic Acid and Two seco-LNA Derivatives and Evaluation of Their Hybridization Properties Compared with Their More Flexible DNA Counterparts-Reference-Cited by-同舟云学术

Synthesis of Abasic Locked Nucleic Acid and Two seco-LNA Derivatives and Evaluation of Their Hybridization Properties Compared with Their More Flexible DNA Counterparts

Published:2000-07-26 Issue:17 Volume:65 Page:5167-5176
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Kværnø Lisbet¹,Kumar Ravindra¹,Dahl Britta M.¹,Olsen Carl Erik¹,Wengel Jesper¹

Affiliation:

1. Center for Synthetic Bioorganic Chemistry, Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark, and Department of Chemistry, The Royal Veterinary and Agricultural University, DK-1871 Frederiksberg, Denmark

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo000275x

Reference34 articles.

1. Investigation of restricted backbone conformations as an explanation for the exceptional thermal stabilities of duplexes involving LNA (Locked Nucleic Acid):† synthesis and evaluation of abasic LNA

2. Acyclic oligonucleotides: possibilities and limitations

3. Preorganization of DNA: Design Principles for Improving Nucleic Acid Recognition by Synthetic Oligonucleotides

4. Nucleic-Acid Analogues with Restricted Conformational Flexibility in the Sugar-Phosphate Backbone (‘bicyclo-DNA’). Part 3. Synthesis, pairing properties, and calorimetric determination of duplex and triplex stability of decanucleotides from [(3′S,5′R)-2′-

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