Gapmer Antisense Oligonucleotides Containing 2′,3′‐Dideoxy‐2′‐fluoro‐3′‐ C ‐hydroxymethyl‐β‐ d ‐lyxofuranosyl Nucleotides Display Site‐Specific RNase H Cleavage and Induce Gene Silencing-Reference-Cited by-同舟云学术

Gapmer Antisense Oligonucleotides Containing 2′,3′‐Dideoxy‐2′‐fluoro‐3′‐ C ‐hydroxymethyl‐β‐ d ‐lyxofuranosyl Nucleotides Display Site‐Specific RNase H Cleavage and Induce Gene Silencing

Published:2020-01-20 Issue:6 Volume:26 Page:1368-1379
ISSN:0947-6539
Container-title:Chemistry – A European Journal
language:en
Short-container-title:Chem. Eur. J.

Author:

Danielsen Mathias B.¹^ORCID,Lou Chenguang¹^ORCID,Lisowiec‐Wachnicka Jolanta²^ORCID,Pasternak Anna²^ORCID,Jørgensen Per T.¹^ORCID,Wengel Jesper¹^ORCID

Affiliation:

1. Biomolecular Nanonscale Engineering CenterDepartment of Physics, Chemistry and PharmacyUniversity of Southern Denmark Campusvej 55 5230 Odense M Denmark

2. Institute of Bioorganic ChemistryPolish Academy of Sciences Z. Noskowskiego 12/14 61-704 Poznań Poland

Funder

Villum Fonden

Publisher

Wiley

Subject

General Chemistry,Catalysis,Organic Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/chem.201904540

Reference35 articles.

1. Chemically modified oligonucleotides with efficient RNase H response

2. RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform