Chemically modified oligonucleotides with efficient RNase H response-Reference-Cited by-同舟云学术

Chemically modified oligonucleotides with efficient RNase H response

Published:2008-04 Issue:7 Volume:18 Page:2296-2300
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Vester Birte,Boel Anne Marie,Lobedanz Sune,Babu B. Ravindra,Raunkjær Michael,Lindegaard Dorthe,Raunak ,Hrdlicka Patrick J.,Højland Torben,Sharma Pawan K.,Kumar Surender,Nielsen Poul,Wengel Jesper

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference32 articles.

1. Molecular mechanisms of action of antisense drugs

2. A critical survey of the structure-function of the antisense oligo/RNA heteroduplex as substrate for RNase H

3. Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)

4. LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

5. Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides

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1. Insertion of a methylene group into the backbone of an antisense oligonucleotide reveals the importance of deoxyribose recognition by RNase H;Organic & Biomolecular Chemistry;2022

2. (S)-5′-C-Aminopropyl-2′-O-methyl nucleosides enhance antisense activity in cultured cells and binding affinity to complementary single-stranded RNA;Bioorganic & Medicinal Chemistry;2021-01

3. Gapmer Antisense Oligonucleotides Containing 2′,3′‐Dideoxy‐2′‐fluoro‐3′‐ C ‐hydroxymethyl‐β‐ d ‐lyxofuranosyl Nucleotides Display Site‐Specific RNase H Cleavage and Induce Gene Silencing;Chemistry – A European Journal;2020-01-20

4. How RNase HI (Escherichia coli) promoted site-selective hydrolysis works on RNA in duplex with carba-LNA and LNA substituted antisense strands in an antisense strategy context?;Molecular BioSystems;2017

5. Evaluation of Multiple-Turnover Capability of Locked Nucleic Acid Antisense Oligonucleotides in Cell-Free RNase H-Mediated Antisense Reaction and in Mice;Nucleic Acid Therapeutics;2014-08