Crystal Structure of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design-Reference-Cited by-同舟云学术

Crystal Structure of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design

Published:2008-11-18 Issue:24 Volume:51 Page:7768-7776
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Montanari Roberta¹,Saccoccia Fulvio¹,Scotti Elena¹,Crestani Maurizio¹,Godio Cristina¹,Gilardi Federica¹,Loiodice Fulvio¹,Fracchiolla Giuseppe¹,Laghezza Antonio¹,Tortorella Paolo¹,Lavecchia Antonio¹,Novellino Ettore¹,Mazza Fernando¹,Aschi Massimiliano¹,Pochetti Giorgio¹

Affiliation:

1. Consiglio Nazionale delle Ricerche, Roma 00016, Italy, Università degli Studi di Milano, Milano 20133, Italy, Università degli Studi di Bari, Bari 70125, Italy, Università degli Studi di Napoli “Federico II”, Napoli 80131, Italy, and Università di L’Aquila, L’Aquila 67010, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800733h

Reference46 articles.

1. The Mechanisms of Action of PPARs

2. PPARs: therapeutic targets for metabolic disease

3. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors and

4. Mechanism of the nuclear receptor molecular switch

5. LIGAND CONTROL OF COREGULATOR RECRUITMENT TO NUCLEAR RECEPTORS

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