Direct Characterization of Drug Glucuronide Isomers in Human Urine by HPLC−NMR Spectroscopy: Application to the Positional Isomers of 6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic Acid Glucuronide-Reference-Cited by-同舟云学术

Direct Characterization of Drug Glucuronide Isomers in Human Urine by HPLC−NMR Spectroscopy: Application to the Positional Isomers of 6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic Acid Glucuronide

Published:1996-09-01 Issue:17 Volume:68 Page:2832-2837
ISSN:0003-2700
Container-title:Analytical Chemistry
language:en
Short-container-title:Anal. Chem.

Author:

Lenz Eva M.¹,Greatbanks David¹,Wilson Ian D.¹,Spraul Manfred¹,Hofmann Martin¹,Troke Jeff¹,Lindon John C.¹,Nicholson Jeremy K.¹

Affiliation:

1. Department of Chemistry, Birkbeck College, University of London, Gordon House, 29 Gordon Square, London WC1H 0PP, U.K., Department of Safety of Medicines, Zeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K., Bruker Analytische Messtechnik GmbH, Silberstreifen, D-76287 Rheinstetten, Germany, and Hoechst-Roussel, Walton Manor, Walton, Milton Keynes, Buckinghamshire MK7 7AJ, U.K.

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ac951228l

Reference18 articles.

1. PH dependent formation of β-glucuronidase resistant conjugates from the biosynthetic ester glucuronide of isoxepac

2. Wilson, I. D.; Bhatti, A.; Illing, H. P. A.; Bryce, T. A.; Chamberlain, J. InDrugMetabolite Isolation and Determination; Reid, E., Leppard, J. P., Eds.; Plenum Press: New York, 1983; pp 181−187.

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