Synthesis of Homochiral 5- and 8- Substituted 2-[((2-(2,6-Dimethoxyphenoxy)- ethyl)amino)methyl]-1,4-benzodioxanes and Electrophoretic Determination of Their Enantiomeric Excess
Author:
Affiliation:
1. Istituto di Chimica Farmaceutica e Tossicologica, Università di Milano, viale Abruzzi 42, I-20131 Milano, Italy, and Pharmacia & Upjohn, viale Pasteur 10, I-20014 Nerviano (MI), Italy %ermanno.valoti@unimi.it
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/jo0008340
Reference5 articles.
1. Pallavicini, M.; Valoti, E.; Villa, L.; Piccolo, O.Tetrahedron: Asymmetry1994,5, 5.
2. Theoretical aspects of chiral separation in capillary electrophoresis
3. Absolute configuration of glycerol derivatives. 4. Synthesis and pharmacological activity of chiral 2-alkylaminomethylbenzodioxans, competitive .alpha.-adrenergic antagonists
4. Absolute configuration of glycerol derivatives. 7. Enantiomers of 2-[[[2-(2,6-dimethoxyphenoxy)ethyl]amino]ethyl]-1,4-benzodioxane (WB-4101), a potent competitive .alpha.-adrenergic antagonist
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