Discovery of a Novel 5-HT3 Antagonist/5-HT1A Agonist 3-Amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an Orally Bioavailable Agent for Irritable Bowel Syndrome-Reference-Cited by-同舟云学术

Discovery of a Novel 5-HT3 Antagonist/5-HT1A Agonist 3-Amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an Orally Bioavailable Agent for Irritable Bowel Syndrome

Published:2010-10-08 Issue:21 Volume:53 Page:7549-7563
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Asagarasu Akira¹,Matsui Teruaki¹,Hayashi Hiroyuki¹,Tamaoki Satoru²,Yamauchi Yukinao²,Minato Kouichi³,Sato Michitaka¹

Affiliation:

1. Synthetic Research Department

2. Pharmacological Research Department

3. Pharmacokinetics Research Department

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1002292

Reference20 articles.

1. Epidemiology of colonic symptoms and the irritable bowel syndrome

2. U. S. Householder survey of functional gastrointestinal disorders

3. Psychologic Considerations in the Irritable Bowel Syndrome

4. Review article: irritable bowel syndrome

5. Arylpiperazines with Serotonin-3 Antagonist Activity: A Comparative Molecular Field Analysis

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