New Insight into the Central Benzodiazepine Receptor–Ligand Interactions: Design, Synthesis, Biological Evaluation, and Molecular Modeling of 3-Substituted 6-Phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and Related Compounds-Reference-Cited by-同舟云学术

New Insight into the Central Benzodiazepine Receptor–Ligand Interactions: Design, Synthesis, Biological Evaluation, and Molecular Modeling of 3-Substituted 6-Phenyl-4H-imidazo[1,5-a][1,4]benzodiazepines and Related Compounds

Published:2011-07-27 Issue:16 Volume:54 Page:5694-5711
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Anzini Maurizio¹,Valenti Salvatore¹,Braile Carlo¹,Cappelli Andrea¹,Vomero Salvatore¹,Alcaro Stefano²,Ortuso Francesco²,Marinelli Luciana³,Limongelli Vittorio³,Novellino Ettore³,Betti Laura⁴,Giannaccini Gino⁴,Lucacchini Antonio⁴,Daniele Simona⁴,Martini Claudia⁴,Ghelardini Carla⁵,Di Cesare Mannelli Lorenzo⁵,Giorgi Gianluca⁶,Mascia Maria Paola⁷⁸,Biggio Giovanni⁷⁸

Affiliation:

1. Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy

2. Dipartimento di Scienze Farmacobiologiche, Università “Magna Græcia” di Catanzaro, Complesso Ninì Barbieri, 88021 Roccelletta di Borgia (CZ), Italy

3. Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli “Federico II”, Via D. Montesano 49, 80131 Napoli, Italy

4. Dipartimento di Psichiatria, Neurobiologia Farmacologia e Biotecnologie, Università di Pisa, Via Bonanno 6, 56126 Pisa, Italy

5. Dipartimento di Farmacologia Preclinica e Clinica “M. Aiazzi Mancini”, Università degli Studi di Firenze, Viale G. Pieraccini 6, 50139 Firenze, Italy

6. Dipartimento di Chimica, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy

7. Dipartimento di Biologia Sperimentale “B. Loddo”, Sezione Neuroscienze, Università degli Studi di Cagliari, Cittadella Universitaria, S.S. 554, Km. 4.500, 09042 Monserrato (CA), Italy

8. Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, Cittadella Universitaria, S.S. 554, Km 4.500, 09042 Monserrato (CA), Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2001597

Reference82 articles.

1. Functional domains of GABAA receptors

2. Introduction: the implications for public health of controls on the benzodiazepines

3. Sulfated and unsulfated steroids modulate γ-aminobutyric acidA receptor function through distinct sites

4. Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives

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