2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: A Potent Human NK1 Receptor Antagonist with Multiple Clearance Pathways-Reference-Cited by-同舟云学术

2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-Bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: A Potent Human NK1 Receptor Antagonist with Multiple Clearance Pathways

Published:2013-07-09 Issue:14 Volume:56 Page:5940-5948
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kassick Andrew J.,Jiang Jinlong,Bunda Jaime,Wilson David,Bao Jianming,Lu Huagang,Lin Peter,Ball Richard G.,Doss George A.,Tong Xinchun,Tsao Kwei-Lan C.,Wang Hong,Chicchi Gary,Karanam Bindhu,Tschirret-Guth Richard,Samuel Koppara,Hora Donald F.,Kumar Sanjeev,Madeira Maria,Eng Waisi¹,Hargreaves Richard¹,Purcell Mona¹,Gantert Liza¹,Cook Jacquelyn¹,DeVita Robert J.,Mills Sander G.

Affiliation:

1. Imaging Research, Merck Research Laboratories, West Point, Pennsylvania 19486, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400751p

Reference23 articles.

1. A non-peptide NK1-receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically

2. Substance P antagonists and analgesia: A review of the hypothesis

3. Preliminary findings on the role of neuropeptide suppression by topical agents in the management of rheumatoid arthritis

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