2-Oxy-3-phenylacrylic acid derivatives as potent Mcl-1 inhibitors for treatment of cancer

Author:

Xi Jiayue,Yao Lin,Zhang Ruyue,Chen Ke,Li Muqiong,Zhang Dongxu,Cui Minxuan,Nie Huifang,Wang Pingan,Li Xiaoye,Jiang RuORCID

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shaanxi Province

Natural Science Basic Research Program of Shaanxi Province

Publisher

Elsevier BV

Subject

General Chemistry

Reference35 articles.

1. Paysant H, Hedir S, Justaud F, Weiswald LB, El Dine AN, Soulieman A, Hachem A, Elie NA-O, Brotin E, Denoyelle C et al: Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues. (1477-0539 (Electronic)).

2. Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity;Bruncko;J. Med. Chem.,2015

3. Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1;Day;J. Mol. Biol.,2008

4. BCL-2 proteins and apoptosis: Recent insights and unknowns;Edlich;Biochem. Biophys. Res. Commun.,2018

5. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy;Czabotar;Nat. Rev. Mol. Cell Biol.,2014

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