Continuous Hydrolysis and Liquid–Liquid Phase Separation of an Active Pharmaceutical Ingredient Intermediate Using a Miniscale Hydrophobic Membrane Separator-Reference-Cited by-同舟云学术

Continuous Hydrolysis and Liquid–Liquid Phase Separation of an Active Pharmaceutical Ingredient Intermediate Using a Miniscale Hydrophobic Membrane Separator

Published:2012-03-07 Issue:5 Volume:16 Page:888-900
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Cervera-Padrell Albert E.¹,Morthensen Sofie T.¹,Lewandowski Daniel J.¹,Skovby Tommy²,Kiil Søren¹,Gernaey Krist V.¹

Affiliation:

1. Department of Chemical and Biochemical Engineering, Technical University of Denmark (DTU), Building 229, DK-2800 Kgs. Lyngby, Denmark

2. Chemical Production Development, H. Lundbeck A/S, Oddenvej 182, DK-4500 Nykoebing Sj., Denmark

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op200242s

Reference44 articles.

1. Extraction based on the flow-injection principle

2. Membrane-based techniques for sample enrichment

3. A microfluidic chip based liquid–liquid extraction system with microporous membrane

4. Integrated continuous microfluidic liquid–liquid extraction

5. Microchemical systems for continuous-flow synthesis

Cited by 61 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Performance of different microfluidic devices in continuous liquid-liquid separation;Journal of Flow Chemistry;2024-06-13

2. Intensification of solvent extraction in an additively manufactured microfluidic separator;Chemical Engineering Journal;2024-03

3. Emerging reaction technologies in pharmaceutical development: Challenges and opportunities in electrochemistry, photochemistry, and biocatalysis;Chemical Engineering Research and Design;2023-04

4. Machine Learning for Two-Phase Flow Separation in a Liquid–Liquid Interface Manipulation Separator;ACS Applied Materials & Interfaces;2023-02-02

5. Purification of Ionic Liquid Solvents in a Self-Optimizing, Continuous Microfluidic Process via Extraction of Metal Ions and Phase Separation;ACS Sustainable Chemistry & Engineering;2022-12-28