A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development-Reference-Cited by-同舟云学术

A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development

Published:2009-08-31 Issue:10 Volume:22 Page:1653-1662
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Walker Don¹,Brady Joe¹,Dalvie Deepak¹,Davis John¹,Dowty Martin¹,Duncan J. Neil¹,Nedderman Angus¹,Obach R. Scott¹,Wright Pat¹

Affiliation:

1. Pharmacokinetics, Dynamics and Metabolism, and Clinical Pharmacology, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, United Kingdom, Drug Safety Research and Development, and Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton, CT 06340, Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, La Jolla, CA 92121, and Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, St. Louis, MO 63141

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx900213j

Reference43 articles.

1. Drug Metabolites in Safety Testing

2. SEEING THROUGH THE MIST: ABUNDANCE VERSUS PERCENTAGE. COMMENTARY ON METABOLITES IN SAFETY TESTING

3. Safety Assessment of Drug Metabolites: Characterization of Chemically Stable Metabolites

4. Approaches to the Assessment of Stable and Chemically Reactive Drug Metabolites in Early Clinical Trials

5. A Regulatory Perspective on Issues and Approaches in Characterizing Human Metabolites

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