Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors-Reference-Cited by-同舟云学术

Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

Published:2007-05-25 Issue:6 Volume:2 Page:408-418
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Fuwa Haruhiko¹,Takahashi Yasuko²,Konno Yu¹,Watanabe Naoto²,Miyashita Hiroyuki²,Sasaki Makoto¹,Natsugari Hideaki³⁴,Kan Toshiyuki⁵⁶,Fukuyama Tohru⁶,Tomita Taisuke²,Iwatsubo Takeshi²

Affiliation:

1. Laboratory of Biostructural Chemistry, Graduate School of Life Sciences, Tohoku University, 1-1 Tsutsumidori-Amamiya, Aoba-ku, Sendai 981-8555, Japan

2. Department of Neuropathology and Neuroscience

3. Laboratory of Synthetic Organic and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Tsukui-gun, Kanagawa 199-0195, Japan

4. Laboratory of Rational Medicinal Science

5. School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan

6. Laboratory of Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/cb700073y

Reference50 articles.

1. γ-Secretase as a Therapeutic Target for Treatment of Alzheimers Disease

2. The multifaceted role of Notch in cancer

3. Identification of Signal Peptide Peptidase, a Presenilin-Type Aspartic Protease

4. The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins

5. Drosophila Signal Peptide Peptidase Is an Essential Protease for Larval Development

Cited by 87 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Photoaffinity labeling and bioorthogonal ligation: Two critical tools for designing “Fish Hooks” to scout for target proteins;Bioorganic & Medicinal Chemistry;2022-05

2. Design, Synthesis, and Utility of Defined Molecular Scaffolds;Organics;2021-07-11

3. γ-Secretase inhibitors for breast cancer and hepatocellular carcinoma: From mechanism to treatment;Life Sciences;2021-03

4. γ-Secretase inhibitors and modulators: Mechanistic insights into the function and regulation of γ-Secretase;Seminars in Cell & Developmental Biology;2020-09

5. Progress in Multicomponent Reactions Involving 1,3-Indanedione;Chinese Journal of Organic Chemistry;2020