Niemann–Pick Type C Disease: A QM/MM Study of Conformational Changes in Cholesterol in the NPC1(NTD) and NPC2 Binding Pockets
Author:
Affiliation:
1. Department of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany
Funder
Volkswagen Foundation
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/bi500548f
Reference33 articles.
1. The Structure of the NPC1L1 N-Terminal Domain in a Closed Conformation
2. Lysosomal Lipid Storage Diseases
3. NPC-db, a Niemann-Pick type C disease gene variation database
4. Current status of drug therapy development for Niemann-Pick type C disease
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1. The Niemann-Pick type diseases – A synopsis of inborn errors in sphingolipid and cholesterol metabolism;Progress in Lipid Research;2023-04
2. Alterations in Cholesterol and Phosphoinositides Levels in the Intracellular Cholesterol Trafficking Disorder NPC;Advances in Experimental Medicine and Biology;2023
3. Molecular dynamics study with mutation shows that N‐terminal domain structural re‐orientation in Niemann‐Pick type C1 is required for proper alignment of cholesterol transport;Journal of Neurochemistry;2020-09-16
4. Signature of N-terminal domain (NTD) structural re-orientation in NPC1 for proper alignment of cholesterol transport: Molecular dynamics study with mutation;2020-06-09
5. The characteristics and biological significance of NPC2: Mutation and disease;Mutation Research/Reviews in Mutation Research;2019-10
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