Molecular dynamics study with mutation shows that N‐terminal domain structural re‐orientation in Niemann‐Pick type C1 is required for proper alignment of cholesterol transport-Reference-Cited by-同舟云学术

Molecular dynamics study with mutation shows that N‐terminal domain structural re‐orientation in Niemann‐Pick type C1 is required for proper alignment of cholesterol transport

Published:2020-09-16 Issue:6 Volume:156 Page:967-978
ISSN:0022-3042
Container-title:Journal of Neurochemistry
language:en
Short-container-title:J. Neurochem.

Author:

Yoon Hye‐Jin¹,Jeong Hyunah²,Lee Hyung Ho¹,Jang Soonmin²^ORCID

Affiliation:

1. Department of Chemistry Seoul National University Seoul Republic of Korea

2. Department of Chemistry Sejong University Seoul Republic of Korea

Funder

National Research Foundation of Korea

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/jnc.15150

Reference51 articles.

1. The lysosome: A potential juncture between SARS‐CoV‐2 infectivity and Niemann‐Pick disease type C, with therapeutic implications

2. MOLEonline 2.0: interactive web-based analysis of biomacromolecular channels

3. Transporters as Drug Targets: Discovery and Development of NPC1L1 Inhibitors

4. Niemann-Pick type C 1 function requires lumenal domain residues that mediate cholesterol-dependent NPC2 binding

5. Niemann–Pick Type C Disease: A QM/MM Study of Conformational Changes in Cholesterol in the NPC1(NTD) and NPC2 Binding Pockets

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