Theoretical Characterization of Substrate Access/Exit Channels in the Human Cytochrome P450 3A4 Enzyme: Involvement of Phenylalanine Residues in the Gating Mechanism-Reference-Cited by-同舟云学术

Theoretical Characterization of Substrate Access/Exit Channels in the Human Cytochrome P450 3A4 Enzyme: Involvement of Phenylalanine Residues in the Gating Mechanism

Published:2009-09-03 Issue:39 Volume:113 Page:13018-13025
ISSN:1520-6106
Container-title:The Journal of Physical Chemistry B
language:en
Short-container-title:J. Phys. Chem. B

Author:

Fishelovitch Dan¹,Shaik Sason¹,Wolfson Haim J.¹,Nussinov Ruth¹

Affiliation:

1. Department of Human Molecular Genetics and Biochemistry, Sackler Institute of Molecular Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel, Institute of Chemistry and the Lise-Meitner-Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel, School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel, and SAIC-Frederick, Inc., Center for Cancer Research...

Publisher

American Chemical Society (ACS)

Subject

Materials Chemistry,Surfaces, Coatings and Films,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp810386z

Reference57 articles.

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2. Heme-Containing Oxygenases

3. Guengerich, F. P.InCytochrome P450: Structure, Mechanism and Biochemistry, 3 ed.Ortiz de Montellano, P. R., Ed.Plenum Press:New York, 2005; pp377−531.

4. The Human Hepatic Cytochromes P450 Involved in Drug Metabolism

5. The ins and outs of cytochrome P450s

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