Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3Kβ Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers-Reference-Cited by-同舟云学术

Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3Kβ Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers

Published:2012-05-02 Issue:10 Volume:55 Page:4788-4805
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Certal Victor¹,Halley Frank¹,Virone-Oddos Angela¹,Delorme Cécile¹,Karlsson Andreas¹,Rak Alexey¹,Thompson Fabienne¹,Filoche-Rommé Bruno¹,El-Ahmad Youssef¹,Carry Jean-Christophe¹,Abecassis Pierre-Yves¹,Lejeune Pascale¹,Vincent Loic¹,Bonnevaux Hélène¹,Nicolas Jean-Paul¹,Bertrand Thomas¹,Marquette Jean-Pierre¹,Michot Nadine¹,Benard Tsiala¹,Below Peter¹,Vade Isabelle¹,Chatreaux Fabienne¹,Lebourg Gilles¹,Pilorge Fabienne¹,Angouillant-Boniface Odile¹,Louboutin Audrey¹,Lengauer Christoph¹,Schio Laurent¹

Affiliation:

1. Oncology Drug Discovery, ‡Structural Biology and Molecular Modeling, §Drug Safety, ∥Protein Production, ⊥Formulation, #Parallel Synthesis, Sanofi Research & Development, 13 quai Jules Guesde, 94403 Vitry-sur-Seine, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300241b

Reference39 articles.

1. Targeting the phosphoinositide 3-kinase pathway in cancer

2. Class I PI3K in oncogenic cellular transformation

3. Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents

4. PTEN-deficient cancers depend on PIK3CB

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