Affiliation:
1. Guangdong Provincial Key Laboratory of New Drug Screening and Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China
Abstract
Imidazole has an important five-membered aromatic heterocyclic ring, which is available
widely in natural products and synthetic molecules. The special structural characteristics of
imidazole ring enable it to bind with a variety of enzymes and receptors through hydrogen bonds,
coordination, ion-dipole and cation-π interactions, hydrophobic effects, and Van der Waals forces.
These interactions promote several biological activities involving anti-tumor, anti-inflammatory,
anti-microbial, and anti-viral properties. Herein, we review and discuss recent developments in using
imidazole derivatives and their special pharmacological activities for the treatment of various
diseases.
Funder
Science and Technology Program of Guangzhou
National Natural Science Foundation of Guangdong Province
National Natural Science Foundation of China
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,General Medicine
Cited by
9 articles.
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