Interaction of amide inhibitors with the active site of carbonic anhydrase: metal-induced deprotonation of the bound amide group is indicated by slow binding kinetics, by visible spectra of complexes with cobalt enzyme, and by pH effects on binding affinity
Author:
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/bi00392a014
Reference39 articles.
1. A new class of inhibitors capable of binding both the acidic and alkaline forms of carbonic anhydrase
2. Metal coordination geometry and mode of action of carbonic anhydrase. Effect of imidazole on the spectral properties of Co(II) and111Cd(II) human carbonic anhydrase B
3. Cobalt(II) as a probe of the structure and function of carbonic anhydrase
4. Binding affinity of bicarboxylate ions for cobalt(II) bovine carbonic anhydrase
5. Characterization of cobalt(II) bovine carbonic anhydrase and of its derivatives
Cited by 27 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Development of Novel Indole-3-sulfonamide-heteroaryl Hybrids as Carbonic Anhydrase Inhibitors: Design, Synthesis and in-vitro Screening;Anti-Cancer Agents in Medicinal Chemistry;2023-07
2. Mechanisms of action of carbonic anhydrase inhibitors;Carbonic Anhydrases;2019
3. Inhibition of carbonic anhydrases by a substrate analog: benzyl carbamate directly coordinates the catalytic zinc ion mimicking bicarbonate binding;Chemical Communications;2018
4. Carbonic Anhydrase as a Model for Biophysical and Physical-Organic Studies of Proteins and Protein−Ligand Binding;Chemical Reviews;2008-03-01
5. Metal Binding Functions in the Design of Carbonic Anhydrase Inhibitors;Current Topics in Medicinal Chemistry;2007-05-01
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3