4,5-Dihydroxypyrimidine Carboxamides and N-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species-Reference-Cited by-同舟云学术

4,5-Dihydroxypyrimidine Carboxamides and N-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species

Published:2006-10-25 Issue:23 Volume:49 Page:6646-6649
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Summa Vincenzo¹,Petrocchi Alessia¹,Matassa Victor G.¹,Gardelli Cristina¹,Muraglia Ester¹,Rowley Michael¹,Paz Odalys Gonzalez¹,Laufer Ralph¹,Monteagudo Edith¹,Pace Paola¹

Affiliation:

1. Departments of Medicinal Chemistry and Drug Metabolism IRBM-MRL Rome, Via Pontina, Km 30.600, 00040 Pomezia, Rome, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060854f

Reference15 articles.

1. Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells

2. Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques

3. Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

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