Orally Bioavailable Antagonists of Inhibitor of Apoptosis Proteins Based on an Azabicyclooctane Scaffold-Reference-Cited by-同舟云学术

Orally Bioavailable Antagonists of Inhibitor of Apoptosis Proteins Based on an Azabicyclooctane Scaffold

Published:2009-02-19 Issue:6 Volume:52 Page:1723-1730
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cohen Frederick¹,Alicke Bruno¹,Elliott Linda O.¹,Flygare John A.¹,Goncharov Tatiana¹,Keteltas Stephen F.¹,Franklin Matthew C.¹,Frankovitz Stacy¹,Stephan Jean-Philippe¹,Tsui Vickie¹,Vucic Domagoj¹,Wong Harvey¹,Fairbrother Wayne J.¹

Affiliation:

1. Departments of Discovery Chemistry, Translational Oncology, Biochemical Pharmacology, Protein Engineering, Assay and Automation Technology, and Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801450c

Reference26 articles.

1. IAP proteins: blocking the road to death's door

2. IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

3. c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

4. IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

5. cIAP1 and cIAP2 Facilitate Cancer Cell Survival by Functioning as E3 Ligases that Promote RIP1 Ubiquitination

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