Confirming Target Engagement for Reversible Inhibitors in Vivo by Kinetically Tuned Activity-Based Probes-Reference-Cited by-同舟云学术

Confirming Target Engagement for Reversible Inhibitors in Vivo by Kinetically Tuned Activity-Based Probes

Published:2012-06-12 Issue:25 Volume:134 Page:10345-10348
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Adibekian Alexander¹²,Martin Brent R.¹²,Chang Jae Won¹²,Hsu Ku-Lung¹²,Tsuboi Katsunori¹²,Bachovchin Daniel A.¹²,Speers Anna E.¹²,Brown Steven J.¹²,Spicer Timothy¹²,Fernandez-Vega Virneliz¹²,Ferguson Jill¹²,Hodder Peter S.¹²,Rosen Hugh¹²,Cravatt Benjamin F.¹²

Affiliation:

1. Skaggs Institute for Chemical Biology and Department of Chemical Physiology and ∥Scripps Research Institute Molecular Screening Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

2. Molecular Screening Center and §Department of Molecular Therapeutics, The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja303400u

Reference22 articles.

1. How Chemoproteomics Can Enable Drug Discovery and Development

2. High-throughput screening assays for the identification of chemical probes

3. Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

4. New approaches for dissecting protease functions to improve probe development and drug discovery

5. Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism

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