Design, Synthesis, and Pharmacological Evaluation of Fluorinated Tetrahydrouridine Derivatives as Inhibitors of Cytidine Deaminase-Reference-Cited by-同舟云学术

Design, Synthesis, and Pharmacological Evaluation of Fluorinated Tetrahydrouridine Derivatives as Inhibitors of Cytidine Deaminase

Published:2014-02-24 Issue:6 Volume:57 Page:2582-2588
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ferraris Dana¹²,Duvall Bridget¹²,Delahanty Greg¹²,Mistry Bipin¹,Alt Jesse¹²,Rojas Camilo¹²,Rowbottom Christopher³,Sanders Kristen³,Schuck Edgar³,Huang Kuan-Chun³,Redkar Sanjeev⁴,Slusher Barbara B.¹²,Tsukamoto Takashi¹²

Affiliation:

1. Eisai Inc., Baltimore, Maryland 21224, United States

2. Brain Science Institute and Department of Neurology, Johns Hopkins University, 855 North Wolfe Street, Suite 231, Baltimore, Maryland 21205, United States

3. Eisai Inc., Andover, Massachusetts 01810, United States

4. Astex Pharmaceuticals, Inc., Dublin, California 94568, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401856k

Reference23 articles.

1. Purification of human cytidine deaminase: Molecular and enzymatic characterization and inhibition by synthetic pyrimidine analogs

2. Studies of the enzymatic deamination of cytosine arabinoside—I

3. Clinical pharmacology and human antitumor activity of cytosine arabinoside