Visible‐Light‐Promoted Difluoromethylation/Cyclization of 1‐Acryloyl‐2‐cyanoindole for Construction of Difluoromethylated Pyrrolo[1,2‐<i>a</i>]indolediones-Reference-Cited by-同舟云学术

Visible‐Light‐Promoted Difluoromethylation/Cyclization of 1‐Acryloyl‐2‐cyanoindole for Construction of Difluoromethylated Pyrrolo[1,2‐a]indolediones

Published:2024-01-23 Issue:5 Volume:366 Page:1158-1164
ISSN:1615-4150
Container-title:Advanced Synthesis & Catalysis
language:en
Short-container-title:Adv Synth Catal

Author:

Qu Hongzhao¹,Yuan Jinwei¹^ORCID,Feng Zhendong¹,Guo Na²,Yin Yanli²,Yang Liangru¹,Xiao Yongmei¹,Qu Lingbo³

Affiliation:

1. School of Chemistry and Chemical Engineering Henan University of Technology Zhengzhou 450001 People's Republic of China

2. College of Advanced Interdisciplinary Science and Technology Henan University of Technology Zhengzhou 450001 People's Republic of China

3. College of Chemistry Zhengzhou University Zhengzhou 450001 People's Republic of China

Abstract

AbstractA visible‐light‐promoted cascade difluoromethylation/cyclization reaction to access various difluoromethylated pyrrolo[1,2‐a]indolediones was developed using difluoromethyltriphenylphosphonium bromide salt as the difluoromethylating reagent. A possible radical mechanism has been investigated and proven as a single electron transfer (SET) procedure.

Funder

Henan University of Technology

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adsc.202301173

Reference66 articles.

2. Hydrogen Bond Donor Properties of the Difluoromethyl Group

3. Synthesis of difluoromethyl substituted lysophosphatidic acid analogues

4. Synthesis of Celecoxib Analogues Possessing a N-Difluoromethyl-1,2-dihydropyrid-2-one 5-Lipoxygenase Pharmacophore: Biological Evaluation as Dual Inhibitors of Cyclooxygenases and 5-Lipoxygenase with Anti-Inflammatory Activity

5. Stereoselective Synthesis of anti-α-(Difluoromethyl)-β-amino Alcohols by Boronic Acid Based Three-Component Condensation. Stereoselective Preparation of (2S,3R)-Difluorothreonine

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