Antitumor Agents. 3. Design, Synthesis, and Biological Evaluation of New Pyridoisoquinolindione and Dihydrothienoquinolindione Derivatives with Potent Cytotoxic Activity-Reference-Cited by-同舟云学术

Antitumor Agents. 3. Design, Synthesis, and Biological Evaluation of New Pyridoisoquinolindione and Dihydrothienoquinolindione Derivatives with Potent Cytotoxic Activity

Published:2004-01-20 Issue:4 Volume:47 Page:849-858
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bolognese Adele¹,Correale Gaetano¹,Manfra Michele¹,Lavecchia Antonio¹,Mazzoni Orazio¹,Novellino Ettore¹,La Colla Paolo¹,Sanna Giuseppina¹,Loddo Roberta¹

Affiliation:

1. Dipartimento di Chimica Organica e Biochimica, Università di Napoli “Federico II”, Via Cynthia 6, Monte Sant'Angelo, I-80126 Napoli, Italy, Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli “Federico II”, Via D. Montesano 49, I-80131 Napoli, Italy, and Dipartimento di Biologia Sperimentale, Sezione di Microbiologia, Università di Cagliari, Cittadella Universitaria SS 554, I-09042 Monserrato, Cagliari, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030918b

Reference28 articles.

1. Chabner, B. A.; Allegra, C. J.; Curt, G. A.; Calabresi, P.; Antineoplastic Agents. InGoodman and Gilman's The Pharmacological Basis ofTherapeutics, 9th ed.; Hardman, J. G., Limbird, L. E., Molinoff, P. B., Ruddon, R. W., Gilman, A. G., Eds.; McGraw-Hill: New York, 1996; pp 1233−1287.

2. Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: Evidence for molecular models involving intercalation

3. Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

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