1. Shimadzu Corporation, Mass Spectrometry Business Unit, Manchester, United Kingdom, Department of Chemistry, Aristotle University of Thessaloniki, 541 24 Greece, AstraZeneca, CPD & DMPK, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG United Kingdom, and Department of Medicine, University of Southern California, Los Angeles, California, United States