IP-LC-MSMS Enables Identification of Three Tau <i>O</i>-GlcNAcylation Sites as <i>O</i>-GlcNAcase Inhibition Pharmacodynamic Readout in Transgenic Mice Overexpressing Human Tau-Reference-Cited by-同舟云学术

IP-LC-MSMS Enables Identification of Three Tau O-GlcNAcylation Sites as O-GlcNAcase Inhibition Pharmacodynamic Readout in Transgenic Mice Overexpressing Human Tau

Published:2023-03-08 Issue:4 Volume:22 Page:1309-1321
ISSN:1535-3893
Container-title:Journal of Proteome Research
language:en
Short-container-title:J. Proteome Res.

Author:

Bijttebier Sebastiaan¹^ORCID,Rodrigues Martins Dina²,Mertens Liesbeth²,Grauwen Karolien²,Bruinzeel Wouter³,Willems Roland²,Bartolomé-Nebreda José Manuel⁴,Theunis Clara²,Bretteville Alexis²,Ebneth Andreas²,Dillen Lieve¹

Affiliation:

1. Bioanalytical Discovery & Development Sciences, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium

2. R&D Neurosciences, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium

3. R&D Structural & Protein Sciences, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium

4. Global Discovery Chemistry, Janssen R&D, Jarama 75A, 45007 Toledo, Spain

Publisher

American Chemical Society (ACS)

Subject

General Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.2c00822

Reference34 articles.

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2. Tau PET in Alzheimer disease and mild cognitive impairment

3. Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease

4. Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates

5. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation

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