The Fit For Purpose Development of S1P1 Receptor Agonist GSK2263167 Using a Robinson Annulation and Saegusa Oxidation to Access an Advanced Phenol Intermediate-Reference-Cited by-同舟云学术

The Fit For Purpose Development of S1P1 Receptor Agonist GSK2263167 Using a Robinson Annulation and Saegusa Oxidation to Access an Advanced Phenol Intermediate

Published:2013-09-24 Issue:10 Volume:17 Page:1239-1246
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Harris Robert M.¹,Andrews Benjamin I.¹,Clark Stacy¹,Cooke Jason W. B.¹,Gray John C. S.¹,Ng Stephanie Q. Q.¹

Affiliation:

1. Chemical Development, GlaxoSmithKline Research and Development Ltd., Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op400162p

Reference19 articles.

1. Synthetic Sphingosine 1-Phosphate Receptor Modulators - Opportunities and Potential Pitfalls

2. Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation

3. Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists

4. Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate

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