Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate-Reference-Cited by-同舟云学术

Discovery of a Selective S1P1 Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate

Published:2011-03-31 Issue:6 Volume:2 Page:444-449
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Demont Emmanuel H.¹,Andrews Benjamin I.¹,Bit Rino A.¹,Campbell Colin A.¹,Cooke Jason W. B.¹,Deeks Nigel¹,Desai Sapna¹,Dowell Simon J.¹,Gaskin Pam¹,Gray James R. J.¹,Haynes Andrea¹,Holmes Duncan S.¹,Kumar Umesh¹,Morse Mary A.¹,Osborne Greg J.¹,Panchal Terry¹,Patel Bela¹,Perboni Alcide¹,Taylor Simon¹,Watson Robert¹,Witherington Jason¹,Willis Robert¹

Affiliation:

1. Immuno Inflammation Center of Excellence for Drug Discovery and ‡Platform Technology and Science, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml2000214

Reference28 articles.

1. Current perspectives on FTY720

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3. Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis

4. Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases

5. Novel Immunomodulator FTY720 Is Phosphorylated in Rats and Humans To Form a Single Stereoisomer. Identification, Chemical Proof, and Biological Characterization of the Biologically Active Species and Its Enantiomer

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