Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema-Reference-Cited by-同舟云学术

Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema

Published:2013-02-01 Issue:2 Volume:4 Page:293-296
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Hilfiker Mark A.,Hoang Tram H.,Cornil Johan,Eidam Hilary S.,Matasic Daniel S.,Roethke Theresa J.,Klein Michael¹,Thorneloe Kevin S.,Cheung Mui

Affiliation:

1. Platform Technology and Science, Molecular Discovery Research, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml300449k

Reference14 articles.

1. The vanilloid transient receptor potential channel TRPV4: From structure to disease

2. TRPV4 Agonists and Antagonists

3. High Vascular Pressure–Induced Lung Injury Requires P450 Epoxygenase–Dependent Activation of TRPV4

4. Negative-Feedback Loop Attenuates Hydrostatic Lung Edema via a cGMP-Dependent Regulation of Transient Receptor Potential Vanilloid 4

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