C-Branched Iminosugars: α-Glucosidase Inhibition by Enantiomers of isoDMDP, isoDGDP, and isoDAB–l-isoDMDP Compared to Miglitol and Miglustat-Reference-Cited by-同舟云学术

C-Branched Iminosugars: α-Glucosidase Inhibition by Enantiomers of isoDMDP, isoDGDP, and isoDAB–l-isoDMDP Compared to Miglitol and Miglustat

Published:2013-06-05 Issue:15 Volume:78 Page:7380-7397
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Jenkinson Sarah F.¹²,Best Daniel¹,Saville A. Waldo¹,Mui James¹,Martínez R. Fernando¹,Nakagawa Shinpei³,Kunimatsu Takahito³,Alonzi Dominic S.²,Butters Terry D.²,Norez Caroline⁴,Becq Frederic⁴,Blériot Yves⁵,Wilson Francis X.⁶,Weymouth-Wilson Alexander C.⁷,Kato Atsushi³,Fleet George W. J.¹²

Affiliation:

1. Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.

2. Oxford Glycobiology Institute, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K.

3. Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

4. Institut de Physiologie et Biologie Cellulaires, Université de Poitiers, CNRS, 40 avenue du Recteur Pineau, 86022 Poitiers, France

5. Equipe “Synthèse Organique” IC2MP, UMR CNRS 7285, Université de Poitiers, 4 rue Michel Brunet, 86022 Poitiers, France

6. Summit PLC, 91, Milton Park, Abingdon, Oxon., OX14 4RY, U.K.

7. Dextra Laboratories Ltd., The Science and Technology Centre, Whiteknights Road, Reading, RG6 6BZ, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo4005487

Reference94 articles.

1. Miglitol

2. Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin

3. Unexpected cure from cutaneous leukocytoclastic vasculitis in a patient treated with N-butyldeoxynojirimycin (miglustat) for Gaucher disease

4. Structure of acid β-glucosidase with pharmacological chaperone provides insight into Gaucher disease

5. Miglustat for treatment of Niemann-Pick C disease: a randomised controlled study

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