Design and synthesis of iso-<i>allo</i>-DNJ and <scp>l</scp>-isoDALDP derivatives: pursuit of potent and selective inhibitors of α-glucosidase-Reference-Cited by-同舟云学术

Design and synthesis of iso-allo-DNJ and l-isoDALDP derivatives: pursuit of potent and selective inhibitors of α-glucosidase

Published:2023 Issue:16 Volume:21 Page:3453-3464
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yang Lin-Feng¹²,Zhang Ming¹³,Shimadate Yuna⁴,Kato Atsushi⁴^ORCID,Hou Tian-Yang Liu¹³,Li Yi-Xian¹³^ORCID,Jia Yue-Mei¹³,Fleet George W. J.⁵^ORCID,Yu Chu-Yi¹³^ORCID

Affiliation:

1. Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

2. High School Attached to Beijing University of Technology, Beijing 100022, China

3. University of Chinese Academy of Sciences, Beijing 100049, China

4. Department of Hospital Pharmacy, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

5. Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK

Abstract

Eight iso-allo-DNJ and l-isoDALDP derivatives were synthesized by a versatile synthetic route, and glycosidase inhibition assay found four of them as selective α-glucosidase inhibitors.

Funder

Japan Society for the Promotion of Science

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00404J

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