Separation and Characterization of Therapeutic Oligonucleotide Isomer Impurities by Cyclic Ion Mobility Mass Spectrometry-Reference-Cited by-同舟云学术

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Separation and Characterization of Therapeutic Oligonucleotide Isomer Impurities by Cyclic Ion Mobility Mass Spectrometry

Published:2024-07-31 Issue:9 Volume:35 Page:2156-2164
ISSN:1044-0305
Container-title:Journal of the American Society for Mass Spectrometry
language:en
Short-container-title:J. Am. Soc. Mass Spectrom.

Author:

Omuro Shogo¹,Yamaguchi Takao¹^ORCID,Kawase Taiji²,Hirose Kenji²,Yoshida Tokuyuki³,Inoue Takao³,Obika Satoshi¹^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan

2. Nihon Waters KK, Kitashinagawa, Shinagawa, Tokyo 140-0001, Japan

3. Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-9501, Japan

Funder

Osaka University

Hoansha Foundation

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/jasms.4c00197

Reference27 articles.

1. Antisense technology: A review

2. Antisense technology: an overview and prospectus

3. Two-dimensional liquid chromatography-mass spectrometry for the characterization of modified oligonucleotide impurities

4. Detecting low-level synthesis impurities in modified phosphorothioate oligonucleotides using liquid chromatography–high resolution mass spectrometry

5. Rapid oligonucleotide drug impurity determination by direct spectral comparison of ion-pair reversed-phase high-performance liquid chromatography electrospray ionization mass spectrometry data

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