Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease-Reference-Cited by-同舟云学术

Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease

Published:1999-07-30 Issue:17 Volume:42 Page:3227-3242
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Camps Pelayo¹,El Achab Rachid¹,Görbig Diana Marina¹,Morral Jordi¹,Muñoz-Torrero Diego¹,Badia Albert¹,Baños Josep Eladi¹,Vivas Nuria María¹,Barril Xavier¹,Orozco Modesto¹,Luque Francisco Javier¹

Affiliation:

1. Laboratori de Química Farmacèutica, Facultat de Farmàcia, Universitat de Barcelona, Av. Diagonal 643, E-08028 Barcelona, Spain, Departament de Farmacologia i de Terapèutica, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193-Bellaterra, Barcelona, Spain, Departament de Físico-Química, Facultat de Farmàcia, Universitat de Barcelona, Av. Diagonal 643, E-08028 Barcelona, Spain, and Departament de Bioquímica, Facultat de Química, Universitat de Barcelona, Av. Martí i Franqués 1, E-08028 Barcelona...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980620z

Reference68 articles.

1. SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE

2. NECROPSY EVIDENCE OF CENTRAL CHOLINERGIC DEFICITS IN SENILE DEMENTIA

3. Pre- and postsynaptic neurochemical alterations in Alzheimer's disease

4. Neurotransmitter-related enzymes in senile dementia of the alzheimer type

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