Huperzine alkaloids: forty years of total syntheses

Author:

Cheng Bichu12ORCID,Song Lili1,Chen Fener132ORCID

Affiliation:

1. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China

2. School of Science, Green Pharmaceutical Engineering Research Center, Harbin Institute of Technology, Shenzhen 518055, China

3. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China

Abstract

This review discusses the synthetic chemistry of huperzine A, a potent inhibitor of acetylcholine esterase (AChE), followed by the advancements in other alkaloids of the family. The analogs and medicinal chemistry of huperzines are summarized.

Funder

Shenzhen Fundamental Research Program

Shenzhen Peacock Plan

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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