ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. 2. Synthesis and Evaluation of (3R*,5S*)-ω-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in Vitro and in Vivo-Reference-Cited by-同舟云学术

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. 2. Synthesis and Evaluation of (3R*,5S*)-ω-Substituted-3-carboxy-3,5-dihydroxyalkanoic Acids and Their γ-Lactone Prodrugs as Inhibitors of the Enzyme in Vitro and in Vivo

Published:1998-08-19 Issue:19 Volume:41 Page:3582-3595
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gribble Andrew D.¹,Ife Robert J.¹,Shaw Antony¹,McNair David¹,Novelli Christine E.¹,Bakewell Susan¹,Shah Virendra P.¹,Dolle Roland E.¹,Groot Pieter H.¹,Pearce Nigel¹,Yates John¹,Tew David¹,Boyd Helen¹,Ashman Stephen¹,Eggleston Drake S.¹,Haltiwanger R. Curtis¹,Okafo George¹

Affiliation:

1. Departments of Medicinal Chemistry, Vascular Biology, Mechanistic Enzymology, and Analytical Sciences, SmithKline Beecham Pharmaceuticals Ltd, New Frontiers Science Park (North), Third Avenue, Harlow, Essex CM19 5AW, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980091z

Reference33 articles.

1. Purification and some kinetic properties of rat liver ATP citrate lyase

2. Purification and Kinetic Studies of the Citrate Cleavage Enzyme

3. (d) Walsh, C.Enzyme ReactionMechanisms; W. H. Freeman and Co. San Francisco, 1979; pp 766−768.

4. ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Design and Synthesis of 2-Substituted Butanedioic Acids as Novel, Potent Inhibitors of the Enzyme

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