ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Design and Synthesis of 2-Substituted Butanedioic Acids as Novel, Potent Inhibitors of the Enzyme-Reference-Cited by-同舟云学术

ATP-Citrate Lyase as a Target for Hypolipidemic Intervention. Design and Synthesis of 2-Substituted Butanedioic Acids as Novel, Potent Inhibitors of the Enzyme

Published:1996-01-01 Issue:18 Volume:39 Page:3569-3584
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gribble Andrew D.¹,Dolle Roland E.¹,Shaw Antony¹,McNair David¹,Novelli Riccardo¹,Novelli Christine E.¹,Slingsby Brian P.¹,Shah Virendra P.¹,Tew David¹,Saxty Barbara A.¹,Allen Mark¹,Groot Pieter H.¹,Pearce Nigel¹,Yates John¹

Affiliation:

1. Departments of Medicinal Chemistry, Mechanistic Enzymology, and Vascular Biology, SmithKline Beecham Pharmaceuticals Ltd, The Frythe, Welwyn, Hertfordshire, AL6 9AR, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960167w

Reference52 articles.

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2. Dysfunctional Properdin in a Dutch Family with Meningococcal Disease

3. HMG‐CoA Reductase Inhibitors: An Exciting Development in the Treatment of Hyperlipoproteinemia

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