Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway-Reference-Cited by-同舟云学术

Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway

Published:2023-12-29 Issue:1 Volume:67 Page:81-109
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Karabanovich Galina¹,Fabiánová Viktória²,Vocat Anthony³,Dušek Jan¹,Valášková Lenka¹,Stolaříková Jiřina⁴,Kitson Russell R. A.¹,Pávek Petr¹,Vávrová Kateřina¹,Djaout Kamel⁵,Mikušová Katarína²,Baulard Alain R.⁵,Cole Stewart T.³,Korduláková Jana²,Roh Jaroslav¹^ORCID

Affiliation:

1. Charles University, Faculty of Pharmacy in Hradec Králové, Akademika Heyrovského 1203, 50005 Hradec Králové, Czech Republic

2. Faculty of Natural Sciences, Department of Biochemistry, Comenius University in Bratislava, Ilkovičova 6, Mlynská dolina, 842 15 Bratislava, Slovakia

3. Global Health Institute, École Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland

4. Regional Institute of Public Health, Department of Bacteriology and Mycology, Partyzánské náměstí 7, 70200 Ostrava, Czech Republic

5. Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France

Funder

Agentura Pro Zdravotnick? V?zkum Cesk? Republiky

European Commission

European Regional Development Fund

Agent?ra na Podporu V?skumu a V?voja

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00925

Reference37 articles.

1. Global tuberculosis report 2022. World Health Organization, Geneva: 2022. Licence: CC BY-NC-SA 3.0 IGO.

2. Delamanid for Multidrug-Resistant Pulmonary Tuberculosis

3. PA-824 Kills Nonreplicating Mycobacterium tuberculosis by Intracellular NO Release

4. Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824

5. Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

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