Synthesis of Akt Inhibitor Ipatasertib. Part 2. Total Synthesis and First Kilogram Scale-up-Reference-Cited by-同舟云学术

Synthesis of Akt Inhibitor Ipatasertib. Part 2. Total Synthesis and First Kilogram Scale-up

Published:2014-11-19 Issue:12 Volume:18 Page:1652-1666
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Remarchuk Travis¹,St-Jean Frederic¹,Carrera Diane¹,Savage Scott¹,Yajima Herbert¹,Wong Brian¹,Babu Srinivasan¹,Deese Alan¹,Stults Jeffrey¹,Dong Michael W.¹,Askin David¹,Lane Jonathan W.²,Spencer Keith L.²

Affiliation:

1. Small Molecule Process Chemistry, Genentech, Inc., a member of the Roche Group, 1 DNA Way, South San Francisco, California 94080-4990, United States

2. Array BioPharma Inc., 3200 Walnut Street, Boulder, Colorado 80301, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op500270z

Reference34 articles.

1. Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

2. Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

3. Synthesis of Akt Inhibitor Ipatasertib. Part 1. Route Scouting and Early Process Development of a Challenging Cyclopentylpyrimidine Intermediate

4. Beight, D. W.; Burkholder, T. P.; Clayton, J. R.; Eggen, M.; Henry, K. J., Jr.; Johns, D. M.; Parthasarathy, S.; Pei, H.; Rempala, M. E.; Sawyer, J. S.AKT Inhibitors. Patent WO2011050016(A1).

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