Efficient Syntheses of AZD4407 via Thioether Formation by Nucleophilic Attack of Organometallic Species on Sulphur-Reference-Cited by-同舟云学术

Efficient Syntheses of AZD4407 via Thioether Formation by Nucleophilic Attack of Organometallic Species on Sulphur

Published:2005-07-15 Issue:5 Volume:9 Page:555-569
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Alcaraz Marie-Lyne¹,Atkinson Stéphanie¹,Cornwall Philip¹,Foster Alison C.¹,Gill Duncan M.¹,Humphries Lesley A.¹,Keegan Philip S.¹,Kemp Richard¹,Merifield Eric¹,Nixon Robert A.¹,Noble Allison J.¹,O'Beirne Darren¹,Patel Zakariya M.¹,Perkins Jacob¹,Rowan Paul¹,Sadler Paul¹,Singleton John T.¹,Tornos James¹,Watts Andrew J.¹,Woodland Ian A.¹

Affiliation:

1. AstraZeneca R&D Charnwood, Process R&D, Bakewell Road, Loughborough, Leicestershire, LE11 5RH, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op0500483

Reference18 articles.

1. Use of a Titanium Thienyl Anion and a Simple Procedure for Introducing a Thiol Group into Thiophene in the Development of a Manufacturing Route to the 5-Lipoxygenase Inhibitor ZD4407

2. Bird, T. G. C.; Ple, P.; Crawley, G. C.; Large, M. S. EP 623614 B1, 1994.

3. Asymmetric Syntheses of (S)-2-Methyl-3,4,5,6-tetrahydro-2H-pyran-4- one and (2S,6S)-2,6-trans-Dimethyl-3,4,5,6-tetrahydro-2H-pyran-4-one Which Employ a Common Lactol Intermediate